Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23410559 | 0.80 | KDM4E (0.44) | KDM4EPDGFRBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8575476 | 0.78 | MAPT (0.50) | KDM4EPDGFRBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22122468 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL11771726 | 0.76 | KDM4E (0.50) | KDM4EPDGFRBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL12735602 | 0.76 | PDGFRB (0.50) | KDM4EPDGFRBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7488038 | 0.75 | PTGS2 (0.52) | — | |
| SCHEMBL6598963 | 0.75 | PDGFRB (0.49) | KDM4EPDGFRBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8508679 | 0.75 | PDGFRB (0.49) | KDM4EPDGFRBALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL1853061 | 0.75 | NPC1 (0.53) | KDM4EPDGFRBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9050978 | 0.74 | KIF11 (0.47) | NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |