Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.49 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081184 | 0.88 | NR3C1 (0.49) | LPAR1LPAR5POLBPTGESNR3C1 | |
| SCHEMBL9079799 | 0.82 | POLB (0.51) | LPAR1LPAR5FFAR1POLBPTGES | |
| SCHEMBL9081339 | 0.81 | LPAR1 (0.45) | LPAR1LPAR5FFAR1POLBPTGES | |
| SCHEMBL9080906 | 0.80 | LPAR1 (0.58) | LPAR1LPAR5POLBPTGESSTAT3 | |
| SCHEMBL9081408 | 0.80 | POLB (0.50) | LPAR1LPAR5POLBPTGESNR3C1 | |
| SCHEMBL9080531 | 0.79 | TSHR (0.55) | LPAR1LPAR5NR3C1STAT3 | |
| SCHEMBL9080371 | 0.79 | TSHR (0.55) | LPAR1LPAR5NR3C1STAT3 | |
| SCHEMBL9081215 | 0.79 | TSHR (0.55) | LPAR1LPAR5NR3C1STAT3 | |
| SCHEMBL9081721 | 0.79 | TSHR (0.55) | LPAR1LPAR5NR3C1STAT3 | |
| SCHEMBL9081660 | 0.79 | NR3C1 (0.44) | LPAR1LPAR5POLBPTGESLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |