Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.50 |
| ▸ | LPAR5 | Q9H1C0 | 7/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9080504 | 0.91 | LPAR1 (0.50) | LPAR1LPAR5PTGESSRD5A2STAT3 | |
| SCHEMBL9080051 | 0.87 | ABCC1 (0.51) | SERPINE1LPAR1LPAR5PTGESSTAT3 | |
| SCHEMBL9081533 | 0.85 | ALDH1A1 (0.54) | LPAR1LPAR5PTGESALDH1A1NPSR1 | |
| SCHEMBL9081830 | 0.82 | LPAR1 (0.57) | LPAR1LPAR5PTGESSRD5A2STAT3 | |
| SCHEMBL9081195 | 0.82 | LPAR1 (0.57) | LPAR1LPAR5PTGESSRD5A2STAT3 | |
| SCHEMBL9080833 | 0.81 | ABCC1 (0.46) | SERPINE1LPAR1LPAR5PTGESSRD5A2 | |
| SCHEMBL9082212 | 0.81 | ALDH1A1 (0.58) | LPAR1LPAR5PTGESSRD5A2ALDH1A1 | |
| SCHEMBL9082700 | 0.80 | ABCC1 (0.45) | SERPINE1LPAR1LPAR5PTGESSTAT3 | |
| SCHEMBL9082264 | 0.79 | ALDH1A1 (0.52) | LPAR1LPAR5PTGESSRD5A2ALDH1A1 | |
| SCHEMBL9081514 | 0.79 | KDM4E (0.66) | LPAR1LPAR5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |