Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017120 | 0.82 | CACNA1H (0.36) | DDAH1POLBGAANPC1RAB9A | |
| SCHEMBL7021216 | 0.82 | DDAH1 (0.53) | DDAH1POLBGAAPKMKDM4E | |
| SCHEMBL7019566 | 0.82 | TDP1 (0.40) | DDAH1POLBGAANPC1RAB9A | |
| SCHEMBL7024978 | 0.79 | DDAH1 (0.39) | DDAH1POLBNPC1RAB9AKDM4E | |
| SCHEMBL698519 | 0.78 | GAA (0.58) | GAANPC1RAB9APKMKDM4E | |
| SCHEMBL7017479 | 0.78 | NPC1 (0.39) | DDAH1GAANPC1RAB9AKDM4E | |
| SCHEMBL7019229 | 0.78 | BCHE (0.38) | DDAH1POLBBCHEPKMKDM4E | |
| SCHEMBL9598374 | 0.78 | MEN1 (0.33) | DDAH1POLBKDM4EALDH1A1TP53 | |
| SCHEMBL11719783 | 0.74 | POLB (0.45) | POLBPKMALDH1A1 | |
| SCHEMBL7020819 | 0.72 | HTT (0.46) | GAANPC1KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |