Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11719783 | 0.88 | POLB (0.45) | POLB | |
| SCHEMBL7021216 | 0.86 | DDAH1 (0.53) | DDAH1POLBKDM4EADORA3ADORA2A | |
| SCHEMBL7019566 | 0.79 | TDP1 (0.40) | DDAH1POLBKDM4ENPC1RAB9A | |
| SCHEMBL7017120 | 0.79 | CACNA1H (0.36) | DDAH1POLBNPC1RAB9A | |
| SCHEMBL908058 | 0.79 | DDAH1 (0.33) | DDAH1POLBKDM4ENPC1RAB9A | |
| SCHEMBL7019229 | 0.79 | BCHE (0.38) | DDAH1POLBKDM4EKMT2AMAPT | |
| SCHEMBL7017479 | 0.79 | NPC1 (0.39) | DDAH1KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL698519 | 0.75 | GAA (0.58) | KDM4ENPC1RAB9AKMT2AMAPT | |
| SCHEMBL9598374 | 0.75 | MEN1 (0.33) | DDAH1POLBKDM4EKMT2AMAPT | |
| SCHEMBL6197934 | 0.74 | RAB9A (0.50) | POLBNPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |