SCHEMBL9080677

SCHEMBL9080677

COc1c(CC#N)cccc1CC#N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
KDM4E B2RXH2 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MAPK1 P28482 2/20 0.36
TDP1 Q9NUW8 1/20 0.34
TSHR P16473 2/20 0.34
DHFR P00374 1/20 0.34
ABCB1 P08183 2/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA14 Q9ULX7 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
ENPP2 Q13822 1/20 0.32
HTR2A P28223 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4160051 0.88 SMN1; SMN2 (0.46) ALDH1A1HPGDKDM4ESMN1; SMN2MAPK1
SCHEMBL27746446 0.87 MEN1 (0.38) ALDH1A1HPGDDHFRHTR2A
SCHEMBL27725691 0.87 SLC6A2 (0.40) ALDH1A1HPGDKDM4ETDP1GAA
SCHEMBL3531950 0.87 GRIA1 (0.40) ALDH1A1HPGDKDM4ESMN1; SMN2TSHR
SCHEMBL31347547 0.87 DHFR (0.36) ALDH1A1HPGDKDM4ESMN1; SMN2MAPK1
SCHEMBL23879261 0.81 MRGPRX4 (0.49) ALDH1A1HPGDKDM4EMAPK1TDP1
SCHEMBL11120686 0.81 ALDH1A1 (0.42) ALDH1A1HPGDKDM4EMAPK1TSHR
SCHEMBL30452297 0.81 MRGPRX4 (0.49) ALDH1A1HPGDKDM4EMAPK1TDP1
SCHEMBL4324495 0.80 ALDH1A1 (0.47) ALDH1A1HPGDKDM4ESMN1; SMN2TSHR
SCHEMBL31347488 0.80 ALDH1A1 (0.64) ALDH1A1HPGDKDM4ESMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0498196-B1 A colorimetric method and reagent for the assay of lithium in a test sample BAYER AG (US) 1996-05-08 EP disclosed
US-5187103-A Chromogenic cryptand MILES INC. (US) 1993-02-16 US disclosed
EP-0498196-A1 A colorimetric method and reagent for the assay of lithium in a test sample Bayer Corporation (US) 1992-08-12 EP disclosed