Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9080677 | 0.87 | ALDH1A1 (0.40) | GRIA1CACNG8KDM4ERAB9ANPC1 | |
| SCHEMBL11125167 | 0.83 | SLC6A2 (0.47) | MAPTMEN1KMT2AP2RX7L3MBTL1 | |
| SCHEMBL11195030 | 0.82 | ALDH1A1 (0.41) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11125781 | 0.82 | PRMT3 (0.40) | GRIA1CACNG8MAPTMEN1KMT2A | |
| SCHEMBL4160051 | 0.80 | SMN1; SMN2 (0.46) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27725691 | 0.79 | SLC6A2 (0.40) | MAPTMEN1KMT2AP2RX7KDM4E | |
| SCHEMBL27746446 | 0.79 | MEN1 (0.38) | MEN1KMT2ACYP1A2ALDH1A1HPGD | |
| SCHEMBL31347547 | 0.79 | DHFR (0.36) | GRIA1CACNG8MAPTMEN1KMT2A | |
| SCHEMBL11239298 | 0.77 | PNMT (0.39) | MAPTMEN1KMT2AP2RX7KDM4E | |
| SCHEMBL10978584 | 0.77 | GABRA1 (0.41) | MAPTMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888259-B1 | DIAZEPINONE DERIVATIVES USEFUL FOR THE TREATMENT OF FRAGILE X SYNDROME, PARKINSONS OR REFLUX DISEASE | NOVARTIS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-20170305903-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2017-10-26 | — | — | US | disclosed |
| US-9650377-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2017-05-16 | — | — | US | disclosed |
| CN-104520298-B | For treating two azepines ketone derivatives of fragile X syndrome, parkinson disease or reflux disease | 诺华股份有限公司 | 2016-10-19 | — | — | CN | disclosed |
| US-20160159795-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2016-06-09 | — | — | US | disclosed |
| CN-105611923-A | Sodium channel modulators for the treatment of pain and diabetes | CHROMOCELL CORP | 2016-05-25 | — | — | CN | disclosed |
| US-9284331-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2016-03-15 | — | — | US | disclosed |
| EP-2888259-A1 | DIAZEPINONE DERIVATIVES USEFUL FOR THE TREATMENT OF FRAGILE X SYNDROME, PARKINSONS OR REFLUX DISEASE | Novartis AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| US-20140357625-A1 | DIAZEPINONE DERIVATIVES | NOVARTIS AG (CH) | 2014-12-04 | — | — | US | disclosed |
| US-8853203-B2 | Diazepinone derivatives | NOVARTIS AG (CH) | 2014-10-07 | — | — | US | disclosed |
| EP-1786823-A1 | ALKYLIDENE TETRAHYDRONAPHTHALENE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-05-23 | — | — | EP | disclosed |
| EP-1670458-B1 | 1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS | SCHERING AG (DE) | 2006-12-20 | — | — | EP | disclosed |
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2006-04-20 | — | — | US | disclosed |
| EP-1638945-A1 | HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2006027236-A1 | ALKYLIDENE TETRAHYDRONAPHTHALENE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-16 | — | — | WO | disclosed |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-12-08 | — | — | US | disclosed |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-09-22 | — | — | US | disclosed |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-08-04 | — | — | US | disclosed |
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-04-28 | — | — | US | disclosed |
| WO-2005003098-A1 | HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090559-A1 | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents | IL1B, NFKBIA, BBOX1 | GRIA1 2217/4885CACNG8 2509/4885MAPT 2912/4885 |
| US-20060084652-A1 | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | PTGES, PTGS1, PTGES2 | GRIA1 2700/4885CACNG8 3924/4885MAPT 2270/4885 |
| US-20160159795-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | GRIA1 57/4885CACNG8 2115/4885MAPT 1174/4885 |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | GRIA1 3266/4885CACNG8 3385/4885MAPT 672/4885 |
| US-20050272823-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, PTGES | GRIA1 2837/4885CACNG8 3758/4885MAPT 964/4885 |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | GRIA1 3266/4885CACNG8 3385/4885MAPT 672/4885 |
| US-20170305903-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | GRIA1 57/4885CACNG8 2115/4885MAPT 1174/4885 |
| US-20140357625-A1 | DIAZEPINONE DERIVATIVES | ADRB1, ADRB2, BRD4 | GRIA1 57/4885CACNG8 2115/4885MAPT 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.