Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11684526 | 0.80 | HPGD (0.37) | NPSR1PTPN1PTPN11ALDH1A1ALOX5 | |
| SCHEMBL18242177 | 0.76 | ALOX5 (0.36) | NPSR1PTPN1PTPN11ALDH1A1ALOX5 | |
| SCHEMBL1206798 | 0.74 | L3MBTL1 (0.69) | L3MBTL1LMNAKEAP1ALDH1A1FFAR1 | |
| SCHEMBL18243922 | 0.74 | PTPN1 (0.34) | NPSR1PTPN1PTPN11ALDH1A1ALOX5 | |
| SCHEMBL18554686 | 0.73 | NPSR1 (0.48) | L3MBTL1NPSR1THRATHRBLMNA | |
| SCHEMBL18242213 | 0.73 | HTT (0.38) | NPSR1PTPN1PTPN11ALDH1A1ALOX5 | |
| SCHEMBL29188156 | 0.73 | NPSR1 (0.53) | L3MBTL1NPSR1KEAP1ALDH1A1GPR17 | |
| SCHEMBL6941987 | 0.73 | PTPN1 (0.41) | L3MBTL1NPSR1THRBLMNAPTPN1 | |
| SCHEMBL11015322 | 0.73 | GAA (0.55) | NPSR1THRATHRBLMNAALDH1A1 | |
| SCHEMBL10879029 | 0.72 | L3MBTL1 (0.72) | L3MBTL1LMNAKEAP1ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0698010-A1 | N-ACYL SULFAMIC ACID ESTERS (OR THIOESTERS), N-ACYL SULFONAMIDES, AND N-SULFONYL CARBAMIC ACID ESTERS (OR THIOESTERS) AS HYPERCHOLESTEROLEMIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1996-02-28 | — | — | EP | disclosed |