Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MC1R | Q01726 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8826281 | 0.87 | LTA4H (0.58) | MC5RMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL30482193 | 0.85 | MC5R (0.70) | MC5RMAPK1MEN1KMT2AMC1R | |
| SCHEMBL2865597 | 0.85 | MC5R (0.70) | MC5RMAPK1MEN1KMT2AMC1R | |
| SCHEMBL15131259 | 0.85 | MEN1 (0.76) | MC5RMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL29766801 | 0.85 | MEN1 (0.76) | MC5RMAPK1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL29519557 | 0.84 | MEN1 (0.74) | MC5RMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL8497858 | 0.82 | KDM4E (0.67) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL7756966 | 0.80 | KDM4E (0.70) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL6008064 | 0.80 | MC5R (0.70) | MC5RMAPK1MEN1KMT2AMC1R | |
| SCHEMBL9080546 | 0.80 | KDM4E (0.61) | MAPK1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |