Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288700 | 0.85 | — | — | |
| SCHEMBL8371948 | 0.76 | ALDH1A1 (0.42) | NPC1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1447729 | 0.74 | MAPT (0.38) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| 4-Formylpyridine SCHEMBL28111845 | 0.73 | ALDH1A1 (0.43) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL7020837 | 0.73 | MAPT (0.50) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL9075652 | 0.71 | SNCA (0.40) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL8200303 | 0.71 | MAPT (0.44) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL151827 | 0.70 | MAPT (0.47) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL151826 | 0.70 | MAPT (0.47) | MAPTSMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL27577717 | 0.70 | CYP3A4 (0.46) | MAPTCYP1A2HPGDCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |