Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.61 |
| ▸ | GART | P22102 | 3/20 | 0.60 |
| ▸ | ATIC | P31939 | 1/20 | 0.60 |
| ▸ | TYMS | P04818 | 4/20 | 0.59 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.53 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.53 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.53 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9085889 | 0.88 | DHFR (0.75) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL8997157 | 0.88 | DHFR (0.65) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9087509 | 0.86 | DHFR (0.67) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9088410 | 0.85 | GART (0.62) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9343717 | 0.84 | DHFR (0.74) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9339239 | 0.82 | GART (0.75) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9339217 | 0.81 | GART (0.74) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9339203 | 0.80 | DHFR (0.69) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL9037916 | 0.80 | DHFR (0.69) | DHFRGARTATICTYMSFOLR2 | |
| SCHEMBL7835435 | 0.80 | DHFR (0.76) | DHFRGARTATICTYMSFOLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496946-A | Production of pyrrolopyrimidines and intermediates therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5349064-A | Production of pyrrolopyrimidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0402903-A1 | Production of pyrrolopyrimidines and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1990-12-19 | — | — | EP | disclosed |