Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175845 | 0.85 | PDPK1 (0.70) | PDPK1RAB9AADRB2LOXL2CYP2A6 | |
| SCHEMBL5692672 | 0.83 | PDPK1 (0.64) | PDPK1RAB9ANPC1ADRB2LOXL2 | |
| SCHEMBL28495166 | 0.83 | PDPK1 (0.52) | PDPK1RAB9ANPC1EDNRBEDNRA | |
| SCHEMBL28487238 | 0.83 | PDPK1 (0.52) | PDPK1RAB9AEDNRBEDNRAADRB2 | |
| SCHEMBL8407091 | 0.83 | PDPK1 (0.52) | PDPK1RAB9AEDNRBEDNRAADRB2 | |
| SCHEMBL558643 | 0.81 | PDPK1 (0.63) | PDPK1RAB9ANPC1PKMRECQL | |
| SCHEMBL1951149 | 0.81 | PDPK1 (0.61) | PDPK1RAB9ANPC1ADRB2LOXL2 | |
| SCHEMBL28355309 | 0.81 | PDPK1 (0.53) | PDPK1RAB9AEDNRBEDNRAADRB2 | |
| SCHEMBL10870937 | 0.80 | F2RL1 (0.47) | PDPK1RAB9ANPC1PKMRECQL | |
| Water SCHEMBL20550178 | 0.80 | ADRB2 (0.62) | PDPK1RAB9ANPC1PKMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583130-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0665748-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | — | 1995-08-23 | — | — | EP | disclosed |
| EP-0665748-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |