Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9090036 | 0.88 | AGTR1 (0.42) | CNR2CNR1AGTR1AGTR2KDM4E | |
| SCHEMBL9090111 | 0.86 | ALDH1A1 (0.48) | CNR2CNR1CYP1A2AGTR1AGTR2 | |
| SCHEMBL7049616 | 0.86 | AGTR1 (0.53) | PTPN1CNR2CNR1AGTR1AGTR2 | |
| SCHEMBL9091321 | 0.85 | CNR2 (0.42) | CNR2CNR1KDM4EMEN1KMT2A | |
| SCHEMBL9090908 | 0.84 | AGTR1 (0.41) | PTPN1CNR2CNR1AGTR1AGTR2 | |
| SCHEMBL9090903 | 0.83 | NAAA (0.43) | CNR2CNR1NPC1RAB9AAGTR1 | |
| SCHEMBL9089034 | 0.83 | KDM4E (0.43) | CNR2CNR1KDM4EMEN1KMT2A | |
| SCHEMBL9091491 | 0.82 | KDM4E (0.38) | CNR2CNR1CYP1A2KDM4EMEN1 | |
| SCHEMBL9090145 | 0.82 | TLR8 (0.39) | CNR2CNR1NPC1RAB9AAGTR1 | |
| SCHEMBL9091009 | 0.79 | PDE4A (0.40) | CNR2CNR1NPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571925-A | HORMONES INHIBITORS FOR HYPOTENSIVE AGENTS | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5563278-A | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0438869-B1 | Improvements in and relating to angiotensin II antagonists | LILLY CO ELI (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5312936-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| US-5073566-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| EP-0438869-A1 | Improvements in and relating to angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1991-07-31 | — | — | EP | disclosed |