Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093955 | 1.00 | HRH3 (0.38) | HRH3DRD2FFAR1GRM2SCN1A | |
| SCHEMBL9093897 | 1.00 | HRH3 (0.38) | HRH3DRD2FFAR1GRM2SCN1A | |
| SCHEMBL9095192 | 0.90 | SLC6A5 (0.36) | HRH3SCN1ASCN5ASCN9AHTR1A | |
| SCHEMBL9096243 | 0.88 | HRH3 (0.41) | HRH3DRD2FFAR1GRM2POLB | |
| SCHEMBL9654252 | 0.88 | CHRNB4 (0.41) | HRH3DRD2FFAR1L3MBTL1HTR1A | |
| SCHEMBL9094570 | 0.85 | DRD2 (0.40) | HRH3DRD2HTR1AHTR7SLC6A4 | |
| SCHEMBL9095130 | 0.85 | DRD2 (0.40) | HRH3DRD2HTR1AHTR7SLC6A4 | |
| SCHEMBL9094038 | 0.85 | DRD2 (0.40) | HRH3DRD2HTR1AHTR7SLC6A4 | |
| SCHEMBL9093992 | 0.85 | EPHX2 (0.34) | HRH3HTR1A | |
| SCHEMBL9654508 | 0.85 | HRH3 (0.41) | HRH3FFAR1GRM2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505465-B1 | 4-Heterocyclyl-piperidine derivatives, their preparation and their use as inhibitors of calcium overload in brain cells | NOVO NORDISK AS (DK) | 1996-03-20 | — | — | EP | claimed |
| US-5102894-A | Antihyporic, antiischemic, antiepileptic agents | NOVO NORDISK A/S (DK) | 1992-04-07 | — | — | US | disclosed |