Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.46 |
| ▸ | CA1 | P00915 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 7/20 | 0.42 |
| ▸ | CA9 | Q16790 | 7/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25073050 | 0.83 | CA2 (0.45) | CA2CA1NPC1ALDH1A1RAB9A | |
| SCHEMBL23794675 | 0.82 | NPC1 (0.50) | CA2CA1NPC1ALDH1A1RAB9A | |
| SCHEMBL9096615 | 0.75 | KDM4E (0.44) | CA2CA1NPC1ALDH1A1RAB9A | |
| SCHEMBL9096195 | 0.72 | LOXL2 (0.53) | CA2CA1CA4CA5ACA5B | |
| SCHEMBL27181485 | 0.71 | ALDH1A1 (0.40) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9262389 | 0.71 | CA2 (0.41) | CA2CA1CA4CA5ACA5B | |
| SCHEMBL25073670 | 0.71 | KDM4E (0.49) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5154428 | 0.71 | ALDH1A1 (0.49) | NPC1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL21962509 | 0.69 | CA2 (0.36) | CA2CA1CA4CA12CA9 | |
| SCHEMBL28259515 | 0.69 | CA2 (0.61) | CA2CA1ALDH1A1CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519040-A | Substituted thiazole sulfonamides as antiglaucoma agents | ALLERGAN (US) | 1996-05-21 | — | — | US | disclosed |
| WO-1995029904-A1 | SUBSTITUTED THIAZOLE SULFONAMIDES AS ANTIGLAUCOMA AGENTS | ALLERGAN (US) | 1995-11-09 | — | — | WO | disclosed |