Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.40 |
| ▸ | FDPS | P14324 | 9/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076633 | 1.00 | CES2 (0.42) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL9785092 | 0.90 | FDPS (0.33) | CES2FDPSTSHR | |
| SCHEMBL9322440 | 0.90 | ACLY (0.43) | — | |
| SCHEMBL9324298 | 0.87 | ACLY (0.39) | — | |
| SCHEMBL76195 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL8374552 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL8856122 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL8401081 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL8354073 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB | |
| SCHEMBL2047066 | 0.81 | GGPS1 (0.40) | CES2GGPS1FDPSTSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498786-A | Synthesis of intermediates in the preparation of ACAT inhibitors | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |