Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786341 | 0.84 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL775333 | 0.82 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL9098395 | 0.79 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL9098509 | 0.79 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL9099501 | 0.76 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL27550563 | 0.76 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL6782503 | 0.76 | PDGFRB (0.54) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL14964814 | 0.75 | SMN1; SMN2 (0.78) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11230580 | 0.72 | MAPT (0.44) | MAPTKDM4ELMNAPDGFRBPDGFRA | |
| SCHEMBL9099431 | 0.71 | CLK4 (0.61) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5507974-A | FOR NONLINEAR OPTICAL APPLICATIONS; FREQUENCY DOUBLING OF LIGHT | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-16 | — | — | US | disclosed |