Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9102458 | 0.97 | MAPT (0.42) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3704087 | 0.92 | TAAR1 (0.44) | MAPTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9103931 | 0.88 | ITGB2 (0.44) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3698675 | 0.88 | ALDH1A1 (0.47) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9105229 | 0.88 | ITGB2 (0.39) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3700824 | 0.88 | ITGB2 (0.37) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9101222 | 0.88 | ITGB2 (0.39) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3698682 | 0.87 | BCHE (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3697146 | 0.86 | KDM4E (0.47) | MAPTALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL3697542 | 0.86 | ITGB2 (0.40) | MAPTALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460798-A2 | APAF-1 INHIBITOR COMPOUNDS | Laboratorios SALVAT, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |