⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413629 | 0.85 | ESR1 (0.45) | — | |
| SCHEMBL598990 | 0.85 | ALDH1A1 (0.39) | — | |
| SCHEMBL3783239 | 0.85 | ALDH1A1 (0.39) | — | |
| SCHEMBL597801 | 0.85 | ALDH1A1 (0.39) | — | |
| SCHEMBL3783240 | 0.85 | ALDH1A1 (0.39) | — | |
| SCHEMBL24980463 | 0.85 | APLNR (0.35) | — | |
| SCHEMBL18742202 | 0.80 | ESR1 (0.31) | — | |
| SCHEMBL15136162 | 0.75 | — | — | |
| SCHEMBL18855248 | 0.75 | — | — | |
| SCHEMBL20381172 | 0.75 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970485-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2024-04-30 | — | — | US | claimed |
| US-11964968-B2 | Compounds useful for inhibiting RET kinase | ELI LILLY AND COMPANY (US) | 2024-04-23 | — | — | US | claimed |
| US-20230312544-A1 | COMPOUNDS USEFUL FOR INHIBITING RET KINASE | LOXO ONCOLOGY, INC. | 2023-10-05 | — | — | US | claimed |
| US-20230265085-A1 | RET KINASE INHIBITORS | LOXO ONCOLOGY, INC. | 2023-08-24 | — | — | US | claimed |
| US-11697647-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2023-07-11 | — | — | US | claimed |
| US-11613533-B2 | Compounds useful for inhibiting RET kinase | ELI LILLY AND COMPANY (US) | 2023-03-28 | — | — | US | claimed |
| EP-4143184-A1 | COMPOUNDS USEFUL FOR INHIBITING RET KINASE | Eli Lilly and Company (US) | 2023-03-08 | — | — | EP | claimed |
| US-20220144816-A1 | RET KINASE INHIBITORS | EVOTEC INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | claimed |
| US-20210363140-A1 | COMPOUNDS USEFUL FOR INHIBITING RET KINASE | LOXO ONCOLOGY, INC. | 2021-11-25 | — | — | US | claimed |
| EP-3907231-A1 | SELECTIVE INHIBITORS OF ALPHA2-CONTAINING ISOFORMS OF NA,K-ATPASE AND USE THEREOF FOR REDUCING INTRAOCULAR PRESSURE | Yeda Research and Development Co., Ltd. (IL) | 2021-11-10 | — | — | EP | claimed |
| WO-2021222017-A1 | COMPOUNDS USEFUL FOR INHIBITING RET KINASE | ELI LILLY AND COMPANY (US) | 2021-11-04 | — | — | WO | claimed |
| EP-3325494-B1 | SELECTIVE INHIBITORS OF ALPHA2-CONTAINING ISOFORMS OF NA,K-ATPASE AND USE THEREOF FOR REDUCING INTRAOCULAR PRESSURE | YEDA RES & DEV (IL) | 2020-12-30 | — | — | EP | claimed |
| US-10668094-B2 | Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2020-06-02 | — | — | US | claimed |
| US-20180207189-A1 | SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2018-07-26 | — | — | US | claimed |
| EP-3325494-A1 | SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE | Yeda Research and Development Co., Ltd. (IL) | 2018-05-30 | — | — | EP | claimed |
| WO-2017013648-A1 | SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-01-26 | — | — | WO | claimed |
| WO-2017013637-A1 | SELECTIVE INHIBITORS OF ALPHA2-CONTAINING ISOFORMS OF NA,K-ATPASE AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-01-26 | — | — | WO | claimed |
| US-11970485-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2024-04-30 | — | — | US | disclosed |
| EP-1941861-A1 | WRINKLE-IMPROVING AGENT | Shiseido Company, Limited (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-1880711-A1 | PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT AND EXTERNAL COMPOSITION FOR SKIN | Shiseido Company, Limited (JP) | 2008-01-23 | — | — | EP | disclosed |