Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301930 | 0.93 | CHRM2 (0.71) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL9107429 | 0.86 | CHRM2 (0.64) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL4859538 | 0.85 | CHRM2 (0.66) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL9111155 | 0.84 | CHRM2 (0.64) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL2448532 | 0.82 | CHRM2 (0.72) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL5346111 | 0.82 | CHRM2 (0.61) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| Cadaverine Tartrate SCHEMBL9104827 | 0.81 | CHRM3 (0.73) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| Cadaverine Tartrate SCHEMBL9104855 | 0.81 | CHRM3 (0.73) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL9109563 | 0.79 | CHRM3 (0.69) | CHRM2CHRM1CHRM3ADRB2CHRM5 | |
| SCHEMBL9109556 | 0.79 | CHRM3 (0.69) | CHRM2CHRM1CHRM3ADRB2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044001-B1 | PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-N-ALKYL-3-PHENYLPROPYLAMINES | LEK PHARMACEUTICALS (SI) | 2016-11-23 | — | — | EP | disclosed |
| US-8193391-B2 | Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N-alkyl-3-phenylpropylamines | LEK PHARMACEUTICALS, D.D. (SI) | 2012-06-05 | — | — | US | disclosed |