Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 8/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21507300 | 0.78 | TLR8 (0.48) | — | |
| SCHEMBL31152270 | 0.78 | TNKS2 (0.39) | WNT3ATNKS2TLR9ROCK2 | |
| SCHEMBL6419598 | 0.77 | TLR8 (0.47) | TLR9 | |
| SCHEMBL1226524 | 0.77 | KDM4E (0.37) | KDM4EWNT3ATNKS2PDK1 | |
| SCHEMBL6420412 | 0.74 | KDM4E (0.35) | KDM4EWNT3ATNKS2CYP2C19PDK1 | |
| SCHEMBL6415688 | 0.74 | TNKS2 (0.42) | KDM4EWNT3ATNKS2CYP2C19PDK1 | |
| SCHEMBL9105964 | 0.73 | WNT3A (0.40) | KDM4EWNT3ATNKS2HRH4CYP2C19 | |
| SCHEMBL31229759 | 0.73 | P2RX3 (0.37) | WNT3ATNKS2 | |
| SCHEMBL21490320 | 0.72 | TLR8 (0.50) | — | |
| SCHEMBL21490321 | 0.72 | TLR8 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459197-A1 | COMPOUNDS FOR THE REDUCTION OF -AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2012-06-06 | — | — | EP | claimed |