Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10258317 | 0.85 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HSD17B10RAB9ACYP1A2 | |
| SCHEMBL9105704 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HSD17B10RAB9ACYP1A2 | |
| SCHEMBL7687953 | 0.77 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HSD17B10CASP1CASP7 | |
| SCHEMBL8107490 | 0.73 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2HSD17B10RAB9ACYP1A2 | |
| SCHEMBL24315862 | 0.73 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HSD17B10CASP1CASP7 | |
| SCHEMBL27167381 | 0.73 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HSD17B10CASP1CASP7 | |
| SCHEMBL2801691 | 0.72 | RAB9A (0.49) | ALDH1A1HSD17B10CASP1CASP7RAB9A | |
| SCHEMBL27167397 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HSD17B10CASP1CASP7 | |
| SCHEMBL16112294 | 0.71 | RAB9A (0.70) | ALDH1A1SMN1; SMN2HSD17B10RAB9ACYP1A2 | |
| SCHEMBL9206577 | 0.70 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2RAB9ACYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816085-B2 | Methylpyrrolopyridinecarboxamides | TAKEDA GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| WO-2011023696-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | ALDH1A1 1112/4885SMN1; SMN2 2053/4885HSD17B10 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.