Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687953 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CASP1CASP7SMN1; SMN2 | |
| SCHEMBL8107490 | 0.76 | ALDH1A1 (0.77) | ALDH1A1HSD17B10SMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL24315862 | 0.75 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CASP1CASP7SMN1; SMN2 | |
| SCHEMBL16112294 | 0.73 | RAB9A (0.70) | ALDH1A1HSD17B10SMN1; SMN2CYP2C9RAB9A | |
| SCHEMBL9106674 | 0.72 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CASP1CASP7SMN1; SMN2 | |
| SCHEMBL10090866 | 0.70 | HPGD (0.55) | ALDH1A1SMN1; SMN2CYP2C9RAB9AMAPT | |
| SCHEMBL2801691 | 0.70 | RAB9A (0.49) | ALDH1A1HSD17B10CASP1CASP7CYP2C9 | |
| SCHEMBL4905420 | 0.69 | ALDH1A1 (0.46) | ALDH1A1HSD17B10SMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL21200870 | 0.68 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CASP1CASP7SMN1; SMN2 | |
| SCHEMBL2159977 | 0.68 | PDE10A (0.49) | ALDH1A1SMN1; SMN2RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262822-A1 | WDR5 INHIBITORS AND MODULATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-08-08 | — | — | US | disclosed |
| EP-4334305-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236101-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2022-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262822-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | ALDH1A1 3561/4885HSD17B10 2723/4885CASP1 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.