Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | KATNA1 | O75449 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107202 | 0.88 | NPC1 (0.41) | KMONPC1RAB9ACYP11B1KATNA1 | |
| SCHEMBL31225056 | 0.83 | KMO (0.40) | KMONPC1RAB9AMAP4K4MINK1 | |
| SCHEMBL3342237 | 0.79 | KDM4E (0.53) | KMONPC1RAB9ACYP11B1KATNA1 | |
| SCHEMBL9104372 | 0.78 | KMO (0.44) | KMOAAK1KDM4EALDH1A1MAPT | |
| SCHEMBL7236570 | 0.70 | CCR1 (0.55) | NPC1RAB9ACYP11B1KATNA1KDM4E | |
| SCHEMBL14989814 | 0.70 | MAPKAPK2 (0.44) | KMOAAK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14926090 | 0.69 | NOS3 (0.34) | MAP4K4MINK1TNIKKDM4EMEN1 | |
| SCHEMBL30041346 | 0.69 | NOS3 (0.34) | MAP4K4MINK1TNIKKDM4EMEN1 | |
| SCHEMBL24759813 | 0.69 | MAPKAPK2 (0.42) | MAP4K4MINK1TNIKAAK1 | |
| SCHEMBL32670883 | 0.69 | MAPKAPK2 (0.42) | MAP4K4MINK1TNIKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563558-B2 | Substituted pyridine urea compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| WO-2012078673-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20120142708-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142708-A1 | SUBSTITUTED PYRIDINE UREA COMPOUNDS | MAPK1, MAP3K1, MAP3K8 | KMO 2754/4885NPC1 2599/4885RAB9A 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.