Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 4/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | KATNA1 | O75449 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18985864 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1POLBLMNAKMO | |
| SCHEMBL1965714 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1POLBLMNANPC1 | |
| SCHEMBL9107202 | 0.81 | NPC1 (0.41) | KDM4EALDH1A1POLBNPC1RAB9A | |
| SCHEMBL14742044 | 0.79 | KMO (0.64) | KDM4EALDH1A1POLBLMNAKMO | |
| SCHEMBL9106834 | 0.79 | KMO (0.40) | KDM4EALDH1A1NPC1RAB9AKMO | |
| SCHEMBL21537437 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1POLBLMNANPC1 | |
| SCHEMBL7236570 | 0.77 | CCR1 (0.55) | KDM4EALDH1A1LMNANPC1RAB9A | |
| SCHEMBL10999252 | 0.76 | AURKB (0.69) | KDM4EALDH1A1POLBLMNAAAK1 | |
| SCHEMBL20732744 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1POLBLMNAKMO | |
| SCHEMBL3342234 | 0.76 | KMO (0.47) | KDM4EALDH1A1POLBLMNAKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | KDM4E 2591/4885ALDH1A1 1506/4885POLB 4104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.