Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592598 | 0.92 | SMN1; SMN2 (0.48) | MEN1KMT2AKDM4ERAB9ANR1I2 | |
| SCHEMBL9885248 | 0.91 | KDR (0.46) | MEN1KMT2AKDM4ERAB9AMAPT | |
| SCHEMBL5592625 | 0.87 | CDK8 (0.44) | MEN1KMT2AKDM4ERAB9ANR1I2 | |
| SCHEMBL5592573 | 0.86 | MEN1 (0.49) | MEN1KMT2AKDM4ERAB9ANR1I2 | |
| SCHEMBL5586121 | 0.86 | BRAF (0.47) | MEN1KMT2AKDM4ERAB9ANR1I2 | |
| Cyclopropane SCHEMBL9108474 | 0.83 | MEN1 (0.46) | MEN1KMT2AKDM4ERAB9AMAPT | |
| Cyclopropane SCHEMBL9104235 | 0.79 | EPHB4 (0.43) | MEN1KMT2AKDM4EMAPTTP53 | |
| SCHEMBL5586117 | 0.78 | MAPT (0.42) | MEN1KMT2AMAPTTHRATHRB | |
| Cyclopropane SCHEMBL9107860 | 0.78 | BRAF (0.43) | THRATHRBBRAF | |
| Cyclopropane SCHEMBL9104865 | 0.78 | KDR (0.45) | MEN1KMT2AKDM4EMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | claimed |