Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.67 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.67 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.67 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.64 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31037050 | 1.00 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL6536466 | 1.00 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL29415087 | 1.00 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL9110079 | 1.00 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| Acetic Acid SCHEMBL11355849 | 0.94 | ALOX15 (0.73) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| Pentachlorophenol SCHEMBL11384430 | 0.91 | ALOX15 (0.69) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL3952646 | 0.88 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL3952647 | 0.88 | ALOX15 (0.79) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL12417301 | 0.88 | ALOX15 (1.00) | ALOX15MAPK1ALDH1A1LMNAPDK1 | |
| SCHEMBL460212 | 0.88 | ALOX15 (1.00) | ALOX15MAPK1ALDH1A1LMNAPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140322304-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION | 2014-10-30 | — | — | US | claimed |
| US-20120141578-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-06-07 | — | — | US | claimed |
| EP-3229811-B1 | PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS | GRI BIO INC (US) | 2021-02-24 | — | — | EP | disclosed |
| US-9839618-B2 | Compositions and methods relating to proliferative diseases | THE PENN STATE RESEARCH FOUNDATION (US) | 2017-12-12 | — | — | US | disclosed |
| US-9839618-B2 | Compositions and methods relating to proliferative diseases | THE PENN STATE RESEARCH FOUNDATION (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170079936-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION | 2017-03-23 | — | — | US | disclosed |
| US-20170079936-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION | 2017-03-23 | — | — | US | disclosed |
| US-9556101-B2 | Compositions and methods relating to proliferative diseases | THE PENN STATE RESEARCH FOUNDATION (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556101-B2 | Compositions and methods relating to proliferative diseases | THE PENN STATE RESEARCH FOUNDATION (US) | 2017-01-31 | — | — | US | disclosed |
| WO-2016094226-A1 | PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS | GLYCOREGIMMUNE, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
| US-20160158258-A1 | PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS | ALTIUM GROWTH FUND, LP | 2016-06-09 | — | — | US | disclosed |
| US-20140322304-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION | 2014-10-30 | — | — | US | disclosed |
| US-8785502-B2 | Compositions and methods relating to proliferative diseases | THE PENN STATE RESEARCH FOUNDATION (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120141578-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | THE PENN STATE RESEARCH FOUNDATION (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140322304-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | PCNA, DERA, TOP2A | ALOX15 552/4885MAPK1 1360/4885ALDH1A1 592/4885 |
| US-20120141578-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | PCNA, DERA, TOP2A | ALOX15 552/4885MAPK1 1360/4885ALDH1A1 592/4885 |
| US-20170079936-A1 | COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES | PCNA, DERA, TOP2A | ALOX15 552/4885MAPK1 1360/4885ALDH1A1 592/4885 |
| US-20160158258-A1 | PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS | RXRA, RXRG, CX3CR1 | ALOX15 1535/4885MAPK1 2188/4885ALDH1A1 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.