Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117039 | 0.86 | MEN1 (0.59) | TACR1MEN1KMT2ATDP1GPR139 | |
| SCHEMBL9114494 | 0.81 | TACR1 (0.64) | TACR1MEN1KMT2ATDP1 | |
| SCHEMBL9116053 | 0.79 | TACR1 (0.62) | TACR1MEN1KMT2ATDP1NPC1 | |
| SCHEMBL17888003 | 0.72 | MEN1 (0.56) | MEN1KMT2ANPC1RAB9ARECQL | |
| SCHEMBL9115325 | 0.72 | MEN1 (0.75) | TACR1MEN1KMT2AGPR139NPC1 | |
| SCHEMBL9114442 | 0.72 | TACR1 (1.00) | TACR1MEN1KMT2ATDP1NPC1 | |
| SCHEMBL139043 | 0.71 | LMNA (0.59) | TACR1MEN1KMT2AGPR139NPC1 | |
| SCHEMBL1162304 | 0.70 | ALDH1A1 (0.50) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL11229863 | 0.70 | ATM (0.68) | MEN1KMT2ARECQLALDH1A1HSD17B10 | |
| SCHEMBL2041891 | 0.70 | KMT2A (0.60) | TACR1MEN1KMT2AGPR139NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995011880-A1 | SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-05-04 | — | — | WO | disclosed |