Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114812 | 1.00 | NR4A1 (0.59) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL27520453 | 0.83 | NR4A1 (0.63) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL14476277 | 0.83 | NR4A1 (0.63) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL9111866 | 0.77 | CES2 (0.55) | NQO2CES2SRD5A2MAOB | |
| SCHEMBL9111870 | 0.77 | CES2 (0.55) | NQO2CES2SRD5A2MAOB | |
| SCHEMBL7804956 | 0.76 | NR4A1 (0.61) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL9610720 | 0.76 | NR4A1 (0.77) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL14604995 | 0.76 | NR4A1 (0.56) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL7799695 | 0.76 | NR4A1 (0.61) | NR4A1NR4A2NR4A3PTGS1PTGS2 | |
| SCHEMBL1474670 | 0.76 | CES2 (0.54) | NR4A1NR4A2NR4A3PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114834-A | antidiabetic agent | OTSUKA PHARMA CO LTD (JP) | 1996-01-10 | — | — | CN | disclosed |
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |