Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28286738 | 0.87 | SLC18A3 (0.61) | SLC18A3GRIN2BCXCR3MCOLN2MCOLN3 | |
| SCHEMBL8569045 | 0.84 | GRIN2B (0.59) | GRIN2BKCNH2HRH3 | |
| SCHEMBL10263767 | 0.84 | SLC18A3 (0.67) | SLC18A3GRIN2BCXCR3MCOLN2MCOLN3 | |
| SCHEMBL27781945 | 0.82 | SLC18A3 (0.65) | SLC18A3CXCR3MCOLN2MCOLN3MCOLN1 | |
| SCHEMBL8434677 | 0.81 | MAOA (0.60) | SLC18A3GRIN2BCXCR3MCOLN2MCOLN3 | |
| SCHEMBL30823779 | 0.80 | SLC18A3 (0.50) | SLC18A3GRIN2BCXCR3MCOLN2MCOLN3 | |
| SCHEMBL25833038 | 0.80 | BRD4 (0.38) | CXCR3CRBNKCNH2HRH3 | |
| SCHEMBL2299038 | 0.79 | SLC18A3 (0.53) | SLC18A3GRIN2BCXCR3MCOLN2MCOLN3 | |
| SCHEMBL29501341 | 0.79 | SLC18A3 (0.53) | SLC18A3CXCR3MAOAMAOBHRH3 | |
| SCHEMBL2657988 | 0.79 | SLC18A3 (0.53) | SLC18A3CXCR3MAOAMAOBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995014469-A1 | NOVEL SPIROCYCLES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| US-5403846-A | Antiarrhythmic agents | MERCK & CO., INC. (US) | 1995-04-04 | — | — | US | disclosed |