Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569629 | 0.91 | GRIN2B (0.62) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL9115585 | 0.84 | SLC18A3 (0.53) | GRIN2BHRH3KCNH2 | |
| SCHEMBL8565348 | 0.82 | GRIN2B (0.53) | GRIN2BOPRL1OPRM1OPRK1TSHR | |
| SCHEMBL12670642 | 0.82 | GRIN2B (0.65) | GRIN2BOPRL1OPRM1OPRK1HRH3 | |
| SCHEMBL20354513 | 0.81 | GRIN2B (0.58) | GRIN2BOPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL13468211 | 0.80 | GRIN2B (0.62) | GRIN2BOPRL1OPRM1OPRK1 | |
| SCHEMBL121604 | 0.79 | L3MBTL3 (0.34) | OPRL1OPRM1OPRK1HRH3KCNH2 | |
| SCHEMBL12309996 | 0.78 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1 | |
| SCHEMBL3089329 | 0.78 | HRH3 (0.61) | GRIN2BOPRL1OPRM1OPRK1HRH3 | |
| SCHEMBL5462211 | 0.78 | SLC18A3 (0.58) | GRIN2BOPRL1OPRM1OPRK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |