SCHEMBL9116325

SCHEMBL9116325

CC(=O)OCCC(CCn1cnc2cnc(N)nc21)(COC(C)=O)COC(C)=O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.61
RXFP1 Q9HBX9 2/20 0.61
KDM4E B2RXH2 1/20 0.61
HPGD P15428 1/20 0.61
ADRA1A P35348 1/20 0.61
HSD17B10 Q99714 1/20 0.61
HDAC6 Q9UBN7 2/20 0.41
HSP90AA1 P07900 3/20 0.38
HSP90AB1 P08238 3/20 0.38
ADORA2B P29275 2/20 0.35
RPS6KA3 P51812 1/20 0.33
TP53 P04637 1/20 0.31
MAPK1 P28482 1/20 0.31
CYP2C19 P33261 1/20 0.31
MEN1 O00255 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
IRAK4 Q9NWZ3 2/20 0.30
ABCB11 O95342 1/20 0.30
POLA1 P09884 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9115124 0.93 KDM4E (0.65) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL9115848 0.85 KDM4E (0.63) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL9115728 0.82 HSP90AB1 (0.43) HDAC6HSP90AA1HSP90AB1
SCHEMBL8926305 0.78 HSD17B10 (0.61) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL9550186 0.77 ALDH1A1 (0.88) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL10646327 0.77 RXFP1 (0.60) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL9116846 0.76 KDM4E (0.53) ALDH1A1RXFP1KDM4EHPGDADRA1A
Famciclovir SCHEMBL29357294 0.76 KDM4E (1.00) ALDH1A1RXFP1KDM4EHPGDADRA1A
SCHEMBL7816738 0.76 KDM4E (0.56) ALDH1A1RXFP1KDM4EHPGDADRA1A
Famciclovir SCHEMBL8190642 0.76 KDM4E (1.00) ALDH1A1RXFP1KDM4EHPGDADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995022330-A1 ANTIVIRAL AGENTS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1995-08-24 WO disclosed