Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.33 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 known ✓ | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 known ✓ | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 known ✓ | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.33 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.33 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.33 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.33 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.33 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.33 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytosine SCHEMBL308339 | 0.98 | — | — | |
| Cytosine SCHEMBL29787229 | 0.98 | POLB (0.42) | POLBNPC1RAB9AAURKAKMT2A | |
| Adenine SCHEMBL30068984 | 0.74 | PI4KA (0.63) | AURKACDC7 | |
| SCHEMBL4795553 | 0.73 | — | — | |
| Guanine SCHEMBL29349830 | 0.73 | PNP (0.72) | KMT2AKDM4EMEN1 | |
| SCHEMBL2927541 | 0.70 | — | — | |
| SCHEMBL29029023 | 0.68 | — | — | |
| Uracil SCHEMBL29525634 | 0.68 | — | — | |
| SCHEMBL30315297 | 0.68 | — | — | |
| SCHEMBL21792155 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664686-A4 | APPARATUS AND METHOD FOR ENHANCED INTRAVASCULAR PHONOPHORESIS INCLUDING DISSOLUTION OF INTRAVASCULAR BLOCKAGE AND CONCOMITANT INHIBITION OF RESTENOSIS. | CORAJE INC (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0664686-A1 | APPARATUS AND METHOD FOR ENHANCED INTRAVASCULAR PHONOPHORESIS INCLUDING DISSOLUTION OF INTRAVASCULAR BLOCKAGE AND CONCOMITANT INHIBITION OF RESTENOSIS | CORAJE, INC. (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994006355-A1 | APPARATUS AND METHOD FOR ENHANCED INTRAVASCULAR PHONOPHORESIS INCLUDING DISSOLUTION OF INTRAVASCULAR BLOCKAGE AND CONCOMITANT INHIBITION OF RESTENOSIS | CORAJE, INC. (US) | 1994-03-31 | — | — | WO | disclosed |