SCHEMBL9116536

SCHEMBL9116536

O=C(CCl)NCCCNC(=O)C(O)Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
ALDH1A2 O94788 1/20 0.48
ALDH2 P05091 1/20 0.48
ALDH1A3 P47895 1/20 0.48
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
USP2 O75604 2/20 0.35
MAPT P10636 1/20 0.35
FAAH O00519 2/20 0.35
TSHR P16473 2/20 0.34
PTGS1 P23219 1/20 0.34
KCNH2 Q12809 1/20 0.34
TEAD1 P28347 1/20 0.33
YAP1 P46937 1/20 0.33
TEAD4 Q15561 1/20 0.33
TEAD2 Q15562 1/20 0.33
DPP7 Q9UHL4 1/20 0.32
CASP2 P42575 1/20 0.31
NAAA Q02083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5830059 0.82 ALDH1A1 (0.83) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3
SCHEMBL14214771 0.79 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3
SCHEMBL7404199 0.77 ALDH1A2 (0.50) ALDH1A1ALDH1A2ALDH2ALDH1A3DPP7
SCHEMBL11127833 0.77 ALDH1A1 (0.94) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3
SCHEMBL11126451 0.74 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3
SCHEMBL16024221 0.72
SCHEMBL5533465 0.71 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2MEN1KMT2AUSP2
SCHEMBL6433502 0.70
SCHEMBL18573847 0.70 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3
SCHEMBL13196281 0.69 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2ALDH1A2ALDH2ALDH1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5464607-A Opacifying agents for X-ray contrast media DIBRA S.P.A. (IT) 1995-11-07 US disclosed
EP-0642492-A1 5,5'-/(1,3-PROPANEDIYL) BIS-/IMINO(2-OXO-2,1-ETHANEDIYL)ACETYLIMINO/BIS(2,4,6-TRIIODO-1,3-BENZENEDICARBOXYAMIDES), AND CONTRAST MEDIA CONTAINING THEM. DIBRA SPA (IT) 1995-03-15 EP disclosed
WO-1993012071-A1 5,5'-/(1,3-PROPANEDIYL) BIS-/IMINO(2-OXO-2,1-ETHANEDIYL)ACETYLIMINO/BIS(2,4,6-TRIIODO-1,3-BENZENEDICARBOXYAMIDES), AND CONTRAST MEDIA CONTAINING THEM BRACCO S.P.A. (IT) 1993-06-24 WO disclosed