Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118627 | 0.84 | HSP90AA1 (0.54) | PTPN1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL9120265 | 0.83 | HSP90AA1 (0.55) | HSD17B10KDM4EALDH1A1HPGDPKM | |
| SCHEMBL7479392 | 0.82 | HTR7 (0.55) | HSD17B10KDM4EALDH1A1HPGDPKM | |
| SCHEMBL9119308 | 0.80 | HSP90AA1 (0.72) | KDM4EHSP90AA1GABRPGABRDGABRA1 | |
| SCHEMBL9117241 | 0.79 | BCAT1 (0.41) | PTPN1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL30615640 | 0.76 | ALDH1A1 (0.56) | HSD17B10KDM4EALDH1A1HPGDPKM | |
| SCHEMBL28904576 | 0.76 | ALDH1A1 (0.56) | HSD17B10KDM4EALDH1A1HPGDPKM | |
| SCHEMBL4644935 | 0.76 | PDE5A (0.52) | HSD17B10KDM4EALDH1A1HPGDGABRP | |
| SCHEMBL18934795 | 0.75 | HSP90AA1 (0.52) | KDM4EHPGDHSP90AA1GABRPGABRD | |
| SCHEMBL5439923 | 0.73 | HSP90AA1 (0.66) | HPGDHSP90AA1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477819-B1 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-03-15 | — | — | EP | disclosed |
| US-5200422-A | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-04-06 | — | — | US | disclosed |
| EP-0477819-A2 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-04-01 | — | — | EP | disclosed |