SCHEMBL9117953

SCHEMBL9117953

CC(C)(C)[Si](Oc1cccc([Mg]Br)c1)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.30
HSP90AB1 P08238 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29910455 0.80 MAOB (0.42)
SCHEMBL4470099 0.80 MAOB (0.42)
SCHEMBL4576487 0.80 CA12 (0.42) HSP90AA1HSP90AB1
SCHEMBL704145 0.79 CA4 (0.37)
SCHEMBL7092637 0.78 CYP3A4 (0.42)
SCHEMBL7227778 0.77 SLC6A2 (0.32)
SCHEMBL8135354 0.77
SCHEMBL31637439 0.77 MAOB (0.49) HSP90AA1
SCHEMBL5352724 0.74
SCHEMBL8537191 0.73 BACE1 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0480708-B1 Hydroxyalkylquinoline ether acids as leukotriene antagonists MERCK FROSST CANADA INC (CA) 1995-10-11 EP disclosed
US-5266568-A Hydroxyalkylquinoline ether acids as leukotriene antagonists MERCK FROSST CANADA, INC. (CA) 1993-11-30 US disclosed
EP-0480708-A2 Hydroxyalkylquinoline ether acids as leukotriene antagonists MERCK FROSST CANADA INC. (CA) 1992-04-15 EP disclosed