Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548369 | 0.80 | MAPT (0.67) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7821052 | 0.76 | LTB4R (0.51) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL14127808 | 0.75 | NCF1 (0.56) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL24744929 | 0.75 | KDM4E (0.52) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL7453174 | 0.75 | POLB (0.40) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7453167 | 0.75 | POLB (0.40) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27596905 | 0.74 | NCF1 (0.54) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL14352239 | 0.74 | NCF1 (0.58) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL14094660 | 0.74 | NCF1 (0.54) | KDM4ENPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL7808259 | 0.73 | NCF1 (0.57) | KDM4ENPC1RAB9AHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |