Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118706 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1EPAS1PSEN1PSEN2 | |
| SCHEMBL9118018 | 0.90 | PTGS2 (0.53) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9118019 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1EPAS1PSEN1PSEN2 | |
| SCHEMBL9118100 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9119913 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1EPAS1HTTSMN1; SMN2 | |
| SCHEMBL9118436 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9118357 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL9118503 | 0.85 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL9119302 | 0.84 | PTGS2 (0.50) | PTGS2PTGS1EPAS1SMN1; SMN2 | |
| SCHEMBL9119080 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1EPAS1USP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |