Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660731 | 0.92 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CYP2C9KCNH2KCNMA1 | |
| SCHEMBL9120300 | 0.86 | CYP2C9 (0.57) | ALDH1A1SMN1; SMN2CYP2C9KCNMA1CACNA1D | |
| SCHEMBL9119962 | 0.82 | CYP2C9 (0.60) | ALDH1A1SMN1; SMN2CYP2C9KCNH2KCNMA1 | |
| SCHEMBL9242712 | 0.81 | CYP2C9 (0.40) | ALDH1A1SMN1; SMN2CYP2C9KCNMA1CACNA1D | |
| SCHEMBL9242708 | 0.81 | CYP2C9 (0.40) | ALDH1A1SMN1; SMN2CYP2C9KCNMA1CACNA1D | |
| SCHEMBL8657124 | 0.77 | HSP90AA1 (0.67) | ALDH1A1CYP2C9KCNMA1CACNA1DLMNA | |
| SCHEMBL5755896 | 0.73 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2CYP2C9HTTLMNA | |
| SCHEMBL8654682 | 0.73 | HSP90AA1 (0.71) | ALDH1A1SMN1; SMN2CYP2C9KCNH2KCNMA1 | |
| SCHEMBL5632612 | 0.73 | MEN1 (0.56) | ALDH1A1SMN1; SMN2HTTLMNAKDM4E | |
| SCHEMBL4931502 | 0.72 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HTTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477819-B1 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-03-15 | — | — | EP | disclosed |
| EP-0477819-A2 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-04-01 | — | — | EP | disclosed |