Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118706 | 0.89 | PTGS2 (0.48) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9118021 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1PKMALDH1A1 | |
| SCHEMBL9118018 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9118436 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9119913 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1EPAS1ALDH1A1MEN1 | |
| SCHEMBL9118660 | 0.86 | PTGS1 (0.48) | PTGS2PTGS1EPAS1ALDH1A1MEN1 | |
| SCHEMBL9117782 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL9118100 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1EPAS1ALDH1A1MEN1 | |
| SCHEMBL9118736 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9119247 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1EPAS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |