Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118021 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1HTTLMNAALDH1A1 | |
| SCHEMBL9118019 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1KMT2AEPAS1 | |
| SCHEMBL9118660 | 0.88 | PTGS1 (0.48) | PTGS2PTGS1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL9119302 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL9116087 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL9119247 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1SMN1; SMN2HTTEPAS1 | |
| SCHEMBL9118706 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117700 | 0.85 | PTGS2 (0.59) | PTGS2PTGS1CA1CA2CA5A | |
| SCHEMBL9117634 | 0.84 | PTGS2 (0.57) | PTGS2PTGS1TSHRSMN1; SMN2HTT | |
| SCHEMBL9117096 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1TSHRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |