SCHEMBL9119616

SCHEMBL9119616

CN=C(Nc1cccc(C(C)(C)C)c1)Nc1cccc(C(C)(C)C)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.53
HDAC3 O15379 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
P2RX1 P51575 1/20 0.47
KCNJ6 P48051 1/20 0.47
KCNJ5 P48544 1/20 0.47
KCNJ3 P48549 1/20 0.47
RAF1 P04049 1/20 0.45
KCNK9 Q9NPC2 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
NPSR1 Q6W5P4 2/20 0.41
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
TP53 P04637 1/20 0.41
CNR1 P21554 2/20 0.40
RXFP1 Q9HBX9 2/20 0.40
FFAR1 O14842 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4979670 0.78 HDAC8 (0.55) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL32675964 0.78 RAF1 (0.65) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL8397802 0.77 KIF11 (0.55) HDAC8HDAC3HDAC6SMN1; SMN2MEN1
SCHEMBL2093458 0.76 HDAC8 (0.62) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL30695893 0.76 HDAC8 (0.62) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL18367692 0.76 HDAC8 (0.54) HDAC8HDAC3HDAC6P2RX1KCNJ6
Bromide SCHEMBL5461571 0.76 HDAC8 (0.54) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL2093456 0.76 HDAC8 (0.62) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL1689404 0.76 HDAC3 (0.62) HDAC8HDAC3HDAC6P2RX1KCNJ6
SCHEMBL9119057 0.76 HDAC8 (0.44) HDAC8HDAC3HDAC6P2RX1KCNJ6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995020950-A1 THERAPEUTIC GUANIDINES CAMBRIDGE NEUROSCIENCE, INC. (US) 1995-08-10 WO disclosed