Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117981 | 0.98 | PIK3CD (0.36) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9237640 | 0.95 | PTGS1 (0.40) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9240663 | 0.88 | GRIN2B (0.34) | PTGS1PTGS2GRIN2BSLC6A7HDAC3 | |
| SCHEMBL9118447 | 0.85 | PTGS2 (0.44) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9118488 | 0.84 | PTGS2 (0.53) | PTGS1PTGS2HDAC3HDAC1HDAC2 | |
| SCHEMBL9118885 | 0.82 | PTGS2 (0.44) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9117616 | 0.81 | PTGS2 (0.53) | PTGS1PTGS2HDAC3HDAC1HDAC2 | |
| SCHEMBL9119117 | 0.80 | PTGS2 (0.44) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9117193 | 0.80 | PTGS2 (0.49) | PIK3CDPIP5K1CPIK3CBPI4KAPIK3CG | |
| SCHEMBL9115540 | 0.79 | GHSR (0.37) | PTGS1PTGS2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |