Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119943 | 1.00 | HCAR2 (0.47) | HCAR2ATMHPGDTSHREPHX1 | |
| SCHEMBL11050866 | 0.90 | TSHR (0.37) | HCAR2ATMHPGDTSHREPHX1 | |
| SCHEMBL10984499 | 0.89 | ATM (0.57) | HCAR2ATMHPGDTSHREPHX1 | |
| SCHEMBL10900619 | 0.85 | EPHX1 (0.58) | HCAR2ATMHPGDTSHREPHX1 | |
| SCHEMBL11593363 | 0.84 | TSHR (0.47) | HCAR2ATMHPGDTSHREPHX1 | |
| SCHEMBL24793666 | 0.83 | NPSR1 (0.52) | HCAR2ATMNPSR1MAPTRAB9A | |
| SCHEMBL1127387 | 0.83 | NPSR1 (0.52) | HCAR2ATMNPSR1MAPTRAB9A | |
| SCHEMBL6570866 | 0.83 | NPSR1 (0.52) | HCAR2ATMNPSR1MAPTRAB9A | |
| SCHEMBL10558937 | 0.82 | HCAR2 (0.46) | HCAR2ATMHPGDTSHRNPSR1 | |
| SCHEMBL10558948 | 0.82 | HCAR2 (0.46) | HCAR2ATMHPGDTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432185-A | Treating patients exhibiting acute or chronic ischaemic disorders associated with disorders of microcirculation, without lowering or increasing blood pressure | BAYER AKTIENGESELLSCHAFT (DE) | 1995-07-11 | — | — | US | disclosed |
| US-5234935-A | Preventing myocardial infarct | BAYER AKTIENGESELLSCHAFT (DE) | 1993-08-10 | — | — | US | disclosed |