SCHEMBL1127387

SCHEMBL1127387

CCOC(=O)C=C(C)NC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.52
HCAR2 Q8TDS4 1/20 0.43
ALDH1A1 P00352 5/20 0.42
LMNA P02545 3/20 0.42
HSD17B10 Q99714 1/20 0.42
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
GLO1 Q04760 1/20 0.38
MAPT P10636 7/20 0.36
KDM4E B2RXH2 3/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
ATM Q13315 1/20 0.36
ALOX15 P16050 1/20 0.36
SOAT1 P35610 1/20 0.36
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24793666 1.00 NPSR1 (0.52) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL6570866 1.00 NPSR1 (0.52) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL30443069 0.89 GAA (0.47) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL11050866 0.84 TSHR (0.37) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL9119949 0.83 HCAR2 (0.47) NPSR1HCAR2ALDH1A1LMNAMAPT
SCHEMBL9119943 0.83 HCAR2 (0.47) NPSR1HCAR2ALDH1A1LMNAMAPT
SCHEMBL11753351 0.81 NPSR1 (0.50) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL5143661 0.81 NPSR1 (0.50) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL19611510 0.81 NPSR1 (0.50) NPSR1HCAR2ALDH1A1LMNAHSD17B10
SCHEMBL10460625 0.81 NPSR1 (0.50) NPSR1HCAR2ALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114334273-A Metal nanowire composite film and preparation method thereof 深圳市善柔科技有限公司 2022-04-12 CN claimed
CN-111269168-B Preparation method of arbidol intermediate 苏州敬业医药化工有限公司 2022-04-01 CN claimed
CN-111269168-A Preparation method of arbidol intermediate 苏州敬业医药化工有限公司 2020-06-12 CN claimed
CN-102260205-A Method for synthesizing Arbidol mesylate 2011-11-30 CN claimed
EP-4294804-B1 PYRIDONE COMPOUNDS AND METHODS OF USE EXELIXIS INC (US) 2026-04-08 EP disclosed
CN-116217461-B Chalcone derivative containing indole structure and preparation method and application thereof 贵州大学 2024-10-18 CN disclosed
US-20240158393-A1 PYRIDONE COMPOUNDS AND METHODS OF USE EXELIXIS, INC. 2024-05-16 US disclosed
CN-117440951-A Pyridone compounds and methods of use 埃克塞里艾克西斯公司 2024-01-23 CN disclosed
EP-4294804-A1 PYRIDONE COMPOUNDS AND METHODS OF USE Exelixis, Inc. (US) 2023-12-27 EP disclosed
CN-116217461-A Chalcone derivative containing indole structure and preparation method and application thereof 贵州大学 2023-06-06 CN disclosed
WO-2022178205-A1 PYRIDONE COMPOUNDS AND METHODS OF USE EXELIXIS, INC. (US) 2022-08-25 WO disclosed
CN-114334273-A Metal nanowire composite film and preparation method thereof 深圳市善柔科技有限公司 2022-04-12 CN disclosed
WO-2000069934-A1 MICROBICIDAL COPOLYMERS CREAVIS GESELLSCHAFT FÜR TECHNOLOGIE UND INNOVATION MBH (DE) 2000-11-23 WO disclosed
WO-2000069933-A1 METHOD FOR PRODUCING INHERENTLY MICROBICIDAL POLYMER SURFACES CREAVIS GESELLSCHAFT FÜR TECHNOLOGIE UND INNOVATION MBH (DE) 2000-11-23 WO disclosed
WO-1999066896-A1 SUN SCREEN FORMULATIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-12-29 WO disclosed
EP-0893119-A1 UV-protection formulation Ciba SC Holding AG (CH) 1999-01-27 EP disclosed
US-RE32975-E FUNGICIDES, BACTERICIDES, FEED ADDITIVES BAYER AKTIENGESELLSCHAFT (DE) 1989-07-04 US disclosed
US-4358606-A Esters of phenalkyloxycarbonylamino acids ZOECON CORPORATION (US) 1982-11-09 US disclosed
US-4284629-A ANIMAL GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1981-08-18 US disclosed
US-3932436-A 2-Thiazolone-5-carboxylic acid ester fungicidal agents BAYER AKTIENGESELLSCHAFT (DT) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158393-A1 PYRIDONE COMPOUNDS AND METHODS OF USE PDXK, PLK2, MAP4K2 NPSR1 4208/4885HCAR2 2963/4885ALDH1A1 4282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.