Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120391 | 0.98 | HTR1A (0.54) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL9119061 | 0.94 | HTR1A (0.53) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL8556355 | 0.81 | HTR1A (0.55) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL8887121 | 0.81 | HTR1A (0.55) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL9441347 | 0.79 | HTR1A (0.54) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL9441283 | 0.79 | HTR1A (0.54) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL9749757 | 0.77 | FAAH (0.46) | HTR1ADRD2HTR7DRD3 | |
| SCHEMBL10581343 | 0.76 | HTR1A (0.50) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL11267626 | 0.74 | HTR1A (0.57) | HTR1ADRD2HTR7HTR2CHRH1 | |
| SCHEMBL20358602 | 0.72 | HTR1A (1.00) | HTR1ADRD2HTR7HTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | claimed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | claimed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | claimed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | disclosed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |