Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458179 | 0.84 | KMT2A (0.55) | KMT2AMEN1NPC1DNMT3ALMNA | |
| SCHEMBL9121700 | 0.77 | KMT2A (0.55) | KMT2AMEN1NPC1LMNAMAPT | |
| SCHEMBL9121706 | 0.77 | KMT2A (0.55) | KMT2AMEN1NPC1LMNAMAPT | |
| SCHEMBL9121723 | 0.76 | KMT2A (0.54) | KMT2AMEN1NPC1DNMT3ALMNA | |
| SCHEMBL9123712 | 0.75 | KMT2A (0.64) | KMT2AMEN1NPC1DNMT3ALMNA | |
| SCHEMBL7898905 | 0.74 | HTR1B (0.42) | KMT2ALMNAMAPT | |
| SCHEMBL8981902 | 0.73 | DNMT3A (0.64) | DNMT3ANLRP3HDAC1HDAC6 | |
| SCHEMBL8981978 | 0.72 | DNMT3A (0.57) | DNMT3ALMNANLRP3HDAC1HDAC6 | |
| SCHEMBL8981982 | 0.72 | DNMT3A (0.57) | DNMT3ALMNANLRP3HDAC1HDAC6 | |
| SCHEMBL8981980 | 0.72 | DNMT3A (0.57) | DNMT3ALMNANLRP3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | claimed |
| EP-0555264-A1 | NOVEL COMPOUNDS | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | claimed |
| WO-1992007850-A1 | NOVEL COMPOUNDS | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | claimed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |