Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | IAPP | P10997 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | TFEB | P19484 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121684 | 1.00 | MAPT (0.58) | MAPTLMNAKDM4EIAPPTDP1 | |
| SCHEMBL11318866 | 0.84 | NFKB1 (0.40) | MAPTLMNAKDM4ETDP1ENPP2 | |
| SCHEMBL9444063 | 0.83 | LMNA (0.54) | MAPTLMNAKDM4EIAPPTDP1 | |
| SCHEMBL9444061 | 0.83 | LMNA (0.54) | MAPTLMNAKDM4EIAPPTDP1 | |
| SCHEMBL11519765 | 0.82 | TDP1 (0.46) | LMNATDP1KMT2AENPP2HTT | |
| SCHEMBL179743 | 0.82 | TDP1 (0.46) | LMNATDP1KMT2AENPP2HTT | |
| SCHEMBL179742 | 0.82 | TDP1 (0.46) | LMNATDP1KMT2AENPP2HTT | |
| SCHEMBL29367457 | 0.82 | TDP1 (0.46) | LMNATDP1KMT2AENPP2HTT | |
| SCHEMBL7042983 | 0.82 | PTPN1 (0.41) | MAPTLMNATDP1ENPP2NFE2L2 | |
| SCHEMBL16494417 | 0.81 | TSHR (0.55) | MAPTLMNAKDM4EIAPPTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512953-B1 | Process for the preparation of benzene sulfonamides | CIBA GEIGY AG (CH) | 1995-06-07 | — | — | EP | claimed |
| US-5220062-A | PROCESS FOR THE PREPARATION OF BENEZENESULFONAMIDES | CIBA-GEIGY CORPORATION (US) | 1993-06-15 | — | — | US | claimed |
| US-5220062-A | PROCESS FOR THE PREPARATION OF BENEZENESULFONAMIDES | CIBA-GEIGY CORPORATION (US) | 1993-06-15 | — | — | US | disclosed |