Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.69 |
| ▸ | CCKAR | P32238 | 4/20 | 0.69 |
| ▸ | CCKBR | P32239 | 4/20 | 0.69 |
| ▸ | PDE4A | P27815 | 7/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.63 |
| ▸ | PDE1A | P54750 | 1/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121125 | 1.00 | SCN9A (0.69) | SCN9ACCKARCCKBRPDE4APDE4B | |
| SCHEMBL9122887 | 0.93 | CCKBR (0.71) | SCN9ACCKARCCKBRPDE4APDE4B | |
| SCHEMBL9124084 | 0.93 | CCKBR (0.71) | SCN9ACCKARCCKBRPDE4APDE4B | |
| SCHEMBL9122695 | 0.83 | PDE4A (0.64) | CCKBRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9122114 | 0.83 | PDE4A (0.64) | CCKBRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9119511 | 0.83 | PDE4A (0.57) | SCN9ACCKARCCKBRPDE4APDE4B | |
| SCHEMBL9526573 | 0.82 | SCN9A (1.00) | SCN9ACCKARCCKBR | |
| SCHEMBL9526577 | 0.82 | SCN9A (1.00) | SCN9ACCKARCCKBR | |
| SCHEMBL9526582 | 0.82 | SCN9A (1.00) | SCN9ACCKARCCKBR | |
| SCHEMBL9293100 | 0.82 | CCKAR (0.75) | SCN9ACCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461048-A | Tricyclic compounds having cholecystokinin antagonist activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5401737-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0360079-B1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-5248679-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| US-5155101-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4981847-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| EP-0360079-A1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-03-28 | — | — | EP | disclosed |