Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120736 | 0.83 | RAB9A (0.48) | RAB9ANPC1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL9827977 | 0.83 | BRAF (0.39) | ACHE | |
| SCHEMBL9123205 | 0.80 | RAB9A (0.41) | RAB9ANPC1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL9120754 | 0.75 | GAA (0.34) | KDM4EALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL9122499 | 0.72 | RAB9A (0.41) | RAB9ANPC1TSHRKDM4EPOLB | |
| SCHEMBL9841834 | 0.72 | ACHE (0.43) | RAB9ANPC1ACHEKDM4ESMN1; SMN2 | |
| SCHEMBL9828458 | 0.71 | RAB9A (0.34) | RAB9ANPC1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL27523883 | 0.71 | TYK2 (0.40) | RAB9ANPC1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL17935193 | 0.69 | CA1 (0.46) | SMN1; SMN2 | |
| SCHEMBL9120125 | 0.68 | JAK2 (0.35) | JAK2JAK1TYK2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428044-A | Anti-inflammatory 4-aminophenyl derivatives | FISONS PLC (GB) | 1995-06-27 | — | — | US | disclosed |
| EP-0425650-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES. | FISONS PLC (GB) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990014338-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES | FISONS PLC (GB) | 1990-11-29 | — | — | WO | disclosed |